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Can I read Repurposing Metformin in hematologic tumor: State of art on EtoBox?
Repurposing Metformin in hematologic tumor: State of art by Min Hu; Yan Chen; Tao Ma; Li Jing is a Medicine article available to read on EtoBox.
What is Repurposing Metformin in hematologic tumor: State of art about?
Metformin is an ancient drug for the treatment of type 2 diabetes, and many studies now suggested that metformin can be used as an adjuvant drug in the treatment of many types of tumors. The mechanism of action of metformin for tumor treatment mainly involves: 1. activation of AMPK signaling pathway 2. inhibition of DNA damage repair in tumor cells 3. downregulation of IGF-1 expression 4. inhibition of chemoresistance and enhancement of chemotherapy sensitivity in tumor cells 5. enhancement of antitumor immunity 6. inhibition of oxidative phosphorylation (OXPHOS). Metformin also plays an important role in the treatment of hematologic tumors, especially in leukemia, lymphoma, and multiple myeloma (MM). The combination of metformin and chemotherapy enhances the efficacy of chemotherapy, and metformin reduces the progression of monoclonal gammopathy of undetermined significance (MGUS) to MM. The purpose of this review is to summarize the anticancer mechanism of metformin and the role and mechanism of action of metformin in hematologic tumors. We mainly summarize the studies related to metformin in hematologic tumors, including cellular experiments and animal experiments, as well as co
Who reads Repurposing Metformin in hematologic tumor: State of art?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Min Hu; Yan Chen; Tao Ma; Li Jing
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)