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Density and Maturity of Peritumoral Tertiary Lymphoid Structures in Oesophageal Squamous Cell Carcinoma Predicts Patient Survival and Response to Immune Checkpoint Inhibitors by Yoshinori Hayashi; Tomoki Makino; Eiichi Sato; Kenji Ohshima; Yuya Nogi; Takashi Kanemura; Keiichiro Honma; Kotaro Yamashita; Takuro Saito; Koji Tanaka; Kazuyoshi Yamamoto; Tsuyoshi Takahashi; Yukinori Kurokawa; Hiroshi Miyata; Kiyokazu Nakajima; Hisashi Wada; Eiichi Morii; Hidetoshi Eguchi; Yuichiro Doki is a Medicine article available to read on EtoBox.

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## Background Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates in non-lymphoid tissues, which are associated with improved prognosis in some cancer types. This study aimed to investigate the clinical significance of TLSs in oesophageal cancer (EC). ## Methods In a series of 316 EC surgical specimens from two different institutes, we evaluated the density and maturity of peritumoral TLSs using haematoxylin/eosin, immunohistochemistry, and multiplex immunofluorescence staining. We analysed the association between TLSs and clinicopathological parameters. The clinical significance of TLSs was further evaluated in a different cohort of 34 patients with recurrent EC treated with anti-PD-1 antibody. ## Results Tumours with high TLS density predominantly consisted of matured TLSs. High TLS density was significantly associated with less advanced tumour stage, absence of lymphatic/vascular invasion, better serum nutrition parameters (neutrophils count, albumin, neutrophil-to-lymphocyte ratio, and prognostic nutritional index), and prolonged survival. This survival trend was more remarkable in cases with matured TLSs, which represented an increased population of CD138^+^ pl

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Author

Yoshinori Hayashi; Tomoki Makino; Eiichi Sato; Kenji Ohshima; Yuya Nogi; Takashi Kanemura; Keiichiro Honma; Kotaro Yamashita; Takuro Saito; Koji Tanaka; Kazuyoshi Yamamoto; Tsuyoshi Takahashi; Yukinori Kurokawa; Hiroshi Miyata; Kiyokazu Nakajima; Hisashi Wada; Eiichi Morii; Hidetoshi Eguchi; Yuichiro Doki

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)