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What is Understanding Renal Bone Disease in CKD about?

1) Chronic kidney disease leads to metabolic bone disease and disturbances in calcium, phosphorus, and bone-regulating hormones like PTH and FGF-23. 2) As kidney function declines, hyperparathyroidism and high bone turnover develop due to phosphate retention and impaired vitamin D activation, stimulating PTH production. 3) Elevated PTH and FGF-23 are early adaptive responses but are associated with bone disease, cardiovascular disease, progression of kidney failure, and mortality in CKD patients.

Author

Elviia Gómez

Language

EN