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Can I read Therapy of a Xenografted Human Colonic Carcinoma Using Cisplatin or Doxorubicin Encapsulated in Long-circulating Pegylated Stealth Liposomes on EtoBox?
Therapy of a Xenografted Human Colonic Carcinoma Using Cisplatin or Doxorubicin Encapsulated in Long-circulating Pegylated Stealth Liposomes by Jan Vaage; Dorothy Donovan; Eirin Wipff; Robert Abra; Gail Colbern; Paul Uster; Peter Working is a Medicine article available to read on EtoBox.
What is Therapy of a Xenografted Human Colonic Carcinoma Using Cisplatin or Doxorubicin Encapsulated in Long-circulating Pegylated Stealth Liposomes about?
We compared the therapeutic effects of low doses of cisplatin and doxorubicin hydrochloride encapsulated in longcirculating liposomes composed of cholesterol/hydrogenated soy phosphatidylcholine-polyethylene glycol-distearoyl-phosphatidyl-ethanolamine. The encapsulation of cisplatin and doxorubicin in these liposomes made ineffectively low doses of the free drugs able to inhibit the growth of and affect cures of a human colonic carcinoma growing in nude mice. Liposome-encapsulated cisplatin had minor systemic toxic side effects indicated by an average 9% weight loss which was recovered 3-4 weeks after the last treatment. Toxicity was not observed in mice treated with liposome-encapsulated doxorubicin.
Who reads Therapy of a Xenografted Human Colonic Carcinoma Using Cisplatin or Doxorubicin Encapsulated in Long-circulating Pegylated Stealth Liposomes?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Jan Vaage; Dorothy Donovan; Eirin Wipff; Robert Abra; Gail Colbern; Paul Uster; Peter Working
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)