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Imaginal cell-specific accumulation of the multicatalytic proteinase complex (proteasome) during post-embryonic development in the tobacco hornworm,Manduca sexta by Hashimoto, Minako K.; Mykles, Donald L.; Schwartz, Lawrence M.; Fahrbach, Susan E. is a scholarly article available to read on EtoBox.

What is Imaginal cell-specific accumulation of the multicatalytic proteinase complex (proteasome) during post-embryonic development in the tobacco hornworm,Manduca sexta about?

The multicatalytic proteinase complex is a multi-subunit, high molecular weight proteinase present in the nucleus and cytoplasm of eukaryotic cells. This catalytic complex is involved in diverse cellular functions as part of the ubiquitin proteolysis system, including nonlysosomal proteolysis, antigen presentation, cell cycle pro ession, and cell proliferation, and in the programmed death of intersegmental muscles after ad It eclosion in the tobacco hornworm complex in the central nervous system of this moth. At all stages of post-embryonic development, most cell types exhibited consistent, low levels of cytoplasmic and nuclear immunoreactivity for the multicatalytic proteinase complex. High levels of cell-specific accumulation of the complex were, however, demonstrated in abdominal neurosecretory cells and in imaginal cells in the larval brain, the larval segmental ganglia, and the developing wing discs. Imaginal cells exhibited intense immunoreactivity for the multicatalytic proteinase complex only until the onset of terminal differentiation. Intersegmental muscles undergoing programmed cell death exhibited intense cytoplasmic immunoreactivity for the multicatalytic proteinase, w

Author

Hashimoto, Minako K.; Mykles, Donald L.; Schwartz, Lawrence M.; Fahrbach, Susan E.

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)

Published

1996

Language

EN