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Predicting Chronic Postsurgical Pain: Current Evidence and a Novel Program to Develop Predictive Biomarker Signatures by Kathleen A. Sluka; Tor D. Wager; Stephani P. Sutherland; Patricia A. Labosky; Tessa Balach; Emine O. Bayman; Giovanni Berardi; Chad M. Brummett; John Burns; Asokumar Buvanendran; Brian Caffo; Vince D. Calhoun; Daniel Clauw; Andrew Chang; Christopher S. Coffey; Dana L. Dailey; Dixie Ecklund; Oliver Fiehn; Kathleen M. Fisch; Laura A. Frey Law; Richard E. Harris; Steven E. Harte; Timothy D. Howard; Joshua Jacobs; Jon M. Jacobs; Kristen Jepsen; Nicolas Johnston; Carl D. Langefeld; Louise C. Laurent; Rebecca Lenzi; Martin A. Lindquist; Anna Lokshin; Ari Kahn; Robert J. McCarthy; Michael Olivier; Linda Porter; Wei-Jun Qian; Cheryse A. Sankar; John Satterlee; Adam C. Swensen; Carol G.T. Vance; Jennifer Waljee; Laura D. Wandner; David A. Williams; Richard L. Wixson; Xiaohong Joe Zhou; the A2CPS Consortium is a Medicine article available to read on EtoBox.

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## Abstract Chronic pain affects more than 50 million Americans. Treatments remain inadequate, in large part, because the pathophysiological mechanisms underlying the development of chronic pain remain poorly understood. Pain biomarkers could potentially identify and measure biological pathways and phenotypical expressions that are altered by pain, provide insight into biological treatment targets, and help identify at-risk patients who might benefit from early intervention. Biomarkers are used to diagnose, track, and treat other diseases, but no validated clinical biomarkers exist yet for chronic pain. To address this problem, the National Institutes of Health Common Fund launched the Acute to Chronic Pain Signatures (A2CPS) program to evaluate candidate biomarkers, develop them into biosignatures, and discover novel biomarkers for chronification of pain after surgery. This article discusses candidate biomarkers identified by A2CPS for evaluation, including genomic, proteomic, metabolomic, lipidomic, neuroimaging, psychophysical, psychological, and behavioral measures. Acute to Chronic Pain Signatures will provide the most comprehensive investigation of biomarkers for the transiti

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Author

Kathleen A. Sluka; Tor D. Wager; Stephani P. Sutherland; Patricia A. Labosky; Tessa Balach; Emine O. Bayman; Giovanni Berardi; Chad M. Brummett; John Burns; Asokumar Buvanendran; Brian Caffo; Vince D. Calhoun; Daniel Clauw; Andrew Chang; Christopher S. Coffey; Dana L. Dailey; Dixie Ecklund; Oliver Fiehn; Kathleen M. Fisch; Laura A. Frey Law; Richard E. Harris; Steven E. Harte; Timothy D. Howard; Joshua Jacobs; Jon M. Jacobs; Kristen Jepsen; Nicolas Johnston; Carl D. Langefeld; Louise C. Laurent; Rebecca Lenzi; Martin A. Lindquist; Anna Lokshin; Ari Kahn; Robert J. McCarthy; Michael Olivier; Linda Porter; Wei-Jun Qian; Cheryse A. Sankar; John Satterlee; Adam C. Swensen; Carol G.T. Vance; Jennifer Waljee; Laura D. Wandner; David A. Williams; Richard L. Wixson; Xiaohong Joe Zhou; the A2CPS Consortium

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2023

Language

EN

Field

Medicine (Health Sciences)