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Can I read Dibenzocycloheptanones construction through a removable P -centered radical: synthesis of allocolchicine analogues† on EtoBox?
Dibenzocycloheptanones construction through a removable P -centered radical: synthesis of allocolchicine analogues† by Yan Zhang; Zhenzhi Cai; Julia Struwe; Chanchan Ma; Wangyu Zeng; Xinyi Liao; Min Xu; Lutz Ackermann is a Chemistry article available to read on EtoBox.
What is Dibenzocycloheptanones construction through a removable P -centered radical: synthesis of allocolchicine analogues† about?
Dibenzocycloheptanones containing a tricyclic 6–7–6-system are present in numerous biologically active natural molecules. However, the simple and efficient preparation of derivatives containing a dibenzocycloheptanone scaffold remains difficult to date. Herein, we report a versatile strategy for the construction of these challenging seven-membered rings using a 7-__endo__-trig cyclization which is initiated by a phosphorus-centered radical. This approach provides a step-economical regime for the facile assembly of a wide range of phosphorylated dibenzocycloheptanones. Remarkably, we also have devised a traceless addition/exchange strategy for the preparation of dephosphorylated products at room temperature with excellent yields. Therefore, this protocol allows for the concise synthesis of biorelevant allocochicine derivatives.
Who reads Dibenzocycloheptanones construction through a removable P -centered radical: synthesis of allocolchicine analogues†?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Yan Zhang; Zhenzhi Cai; Julia Struwe; Chanchan Ma; Wangyu Zeng; Xinyi Liao; Min Xu; Lutz Ackermann
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2021
- Language
- EN
- Field
- Chemistry (Physical Sciences)