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Can I read Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening on EtoBox?
Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening by Taikou Usui; Hyun Seung Ban; Junpei Kawada; Takatsugu Hirokawa; Hiroyuki Nakamura is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening about?
A series of indenopyrazoles 8 and 9 were designed and synthesized as EGFR tyrosine kinase inhibitors by in silico highthroughput screening. Compounds 8b and 8d showed significant inhibition of A431 cell growth (GI 50 = 0.062 and 0.057 lM, respectively). Compounds 8b and 9a showed inhibitory activity toward both EGFR and VEGFR-2 (KDR) tyrosine kinases, whereas 8d inhibited VEGFR-2 tyrosine kinase, exclusively.
Who reads Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Taikou Usui; Hyun Seung Ban; Junpei Kawada; Takatsugu Hirokawa; Hiroyuki Nakamura
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)