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Antiphospholipid Syndrome During Chronic Myelomonocytic Leukemia by Viallard, J.F.; Marit, G.; Reiffers, J.; Broustet, A.; Parrens, M. is a Medicine article available to read on EtoBox.

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## Disseminated Histoplasmosis Following Prolonged Low-Dose Methotrexate Therapy To the Editor: A 43-year-old woman from central Minnesota presented to her primary internist with a 4-month history of weight loss and abdominal distension and a 2-week history of fevers, sweats, weakness, and anorexia. She was receiving treatment with low-dose methotrexate (15 mg every week) for the last 5 years for rheumatoid arthritis. Splenomegaly was noted on examination. Her hemoglobin was 11.5 g/dl, leukocyte count (WBC) was 3.2 × 10 9 /l, and platelets were 115 × 10 9 /l. Routine liver and renal function tests were normal. Bone marrow biopsy showed normocellular marrow with normal trilineage hematopoiesis. A diagnosis of felty's syndrome was made, and treatment with prednisone, 60 mg per day, was started. Her symptoms continued to progress. She was referred to the University of Minnesota for a second opinion 2 weeks later. On examination weight loss, splenomegaly (25 cm below the costal margin), and ascites was noted. Her pancytopenia had progressed: hemoglobin, 8.2 g/dl; WBC, 1.8 × 10 9 /l (56% neutrophils); platelets, 49 × 10 9 /l; and reticulocyte count, 10%. Serum albumin was 2.1 g/dl, bili

Who reads Antiphospholipid Syndrome During Chronic Myelomonocytic Leukemia?

Author

Viallard, J.F.; Marit, G.; Reiffers, J.; Broustet, A.; Parrens, M.

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0361-8609)

Published

2000

Language

EN

Field

Medicine (Health Sciences)