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Can I read A Critical Appraisal of Evidence on the Efficacy and Safety of Serotonergic Psychedelic Drugs as Emerging Antidepressants: Mind the Evidence Gap on EtoBox?
A Critical Appraisal of Evidence on the Efficacy and Safety of Serotonergic Psychedelic Drugs as Emerging Antidepressants: Mind the Evidence Gap by Nicole Ledwos; Joshua D. Rosenblat; Daniel M. Blumberger; David J. Castle; Roger S. McIntyre; Benoit H. Mulsant; M. Ishrat Husain is a Medicine article available to read on EtoBox.
What is A Critical Appraisal of Evidence on the Efficacy and Safety of Serotonergic Psychedelic Drugs as Emerging Antidepressants: Mind the Evidence Gap about?
## Purpose/background: There has been resurgence of interest in the therapeutic use of serotonergic ("classic") psychedelics in major depressive disorder (mdd) and end-of-life distress. this commentary offers a critical appraisal of current evidence for antidepressant effects of classic psychedelics from contemporary clinical trials and highlights pitfalls that should be addressed before clinical translation. ## Methods/procedures: A narrative review was conducted to identify clinical trials of serotonergic psychedelics for the treatment of mdd and end-of-life distress. trials published between january 1990 and may 2022 were identified on pubmed using combinations of search terms. ## Findings/results: Psilocybin, lysergic acid diethylamide, and ayahuasca have clinical trials to evaluate antidepressant effects. two studies showed preliminary positive effects of single-dose ayahuasca for treatment-resistant depression. similar results were seen in lysergic acid diethylamide for end-of-life distress. small randomized clinical trials (rcts) of psilocybin combined with psychotherapy showed superiority to waitlist controls and comparable efficacy and safety to an active comparator in mdd
Who reads A Critical Appraisal of Evidence on the Efficacy and Safety of Serotonergic Psychedelic Drugs as Emerging Antidepressants: Mind the Evidence Gap?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Nicole Ledwos; Joshua D. Rosenblat; Daniel M. Blumberger; David J. Castle; Roger S. McIntyre; Benoit H. Mulsant; M. Ishrat Husain
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)