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Increased expression of prostate‐specific G‐protein‐coupled receptor in human prostate intraepithelial neoplasia and prostate cancers by Jinsheng Weng; Jianghua Wang; Yi Cai; Lewis Joe Stafford; Dianne Mitchell; Michael Ittmann; Mingyao Liu is a Medicine article available to read on EtoBox.

What is Increased expression of prostate‐specific G‐protein‐coupled receptor in human prostate intraepithelial neoplasia and prostate cancers about?

## Abstract The G‐protein‐coupled receptors and signal transduction pathways represent important specific targets for a variety of human diseases, ranging from the control of blood pressure, allergic response, hormonal disorders and neurologic diseases to tumorigenesis. Most recently, we and others have identified a novel human prostate‐specific G‐protein coupled receptor (PSGR). To investigate the potential roles of PSGR in human normal prostate and prostate cancers, we examined the expression level of PSGR in 146 human prostate samples with real‐time quantitative reverse transcription‐PCR and __in situ__ hybridization method. We significantly extended previous studies and demonstrated that PSGR is specifically expressed in human prostate tissues, not in any other normal and tumor samples tested. Compared to normal and benign prostatic hyperplasia tissues, the expression of __PSGR__ increased significantly in human prostate intraepithelial neoplasia (PIN) and prostate tumors (approximately 10‐fold), especially in early prostate tumors, suggesting PSGR may play an important role in early prostate cancer development and progression. The sensitivity and specificity estimates for PSGR

Who reads Increased expression of prostate‐specific G‐protein‐coupled receptor in human prostate intraepithelial neoplasia and prostate cancers?

Author

Jinsheng Weng; Jianghua Wang; Yi Cai; Lewis Joe Stafford; Dianne Mitchell; Michael Ittmann; Mingyao Liu

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2004

Language

EN

Field

Medicine (Health Sciences)