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The document reviews the transformative impact of CRISPR-Cas9 technology in genetic disease therapeutics, detailing its molecular mechanisms, clinical applications, and recent advancements such as base and prime editing. It highlights landmark clinical trials, including the FDA-approved exa-cel for sickle cell disease and beta-thalassemia, and discusses ongoing challenges such as off-target effects and ethical considerations surrounding germline editing. The review concludes that CRISPR-based therapies are

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