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Body-mass index, blood pressure, diabetes and cardiovascular mortality in Cuba: prospective study of 146,556 participants by Armas Rojas, Nurys B (author);Lacey, Ben (author);Soni, Monica (author);Charles, Shaquille (author);Carter, Jennifer (author);Varona-Pérez, Patricia (author);Burrett, Julie Ann (author);Martínez, Marcy Calderón (author);Lorenzo-Vázquez, Elba (author);Constantén, Sonia Bess (author);Taylor, Hannah (author);Sherliker, Paul (author);Rigau, José Manuel Morales (author);Ross, Stephanie (author);Massa, M. Sofia (author);López, Osvaldo Jesús Hernández (author);Islam, Nazrul (author);Morales, Miguel Ángel Martínez (author);Alomá, Ismell Alonso (author);Estupiñan, Fernando Achiong (author);González, Mayda Díaz (author);Muñoz, Noel Rosquete (author);Asencio, Marelis Cendra (author);Díaz-Diaz, Oscar (author);Iglesias-Marichal, Ileydis (author);Emberson, Jonathan (author);Peto, Richard (author);Lewington, Sarah (author) is a Medicine article available to read on EtoBox.

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## Background Cardiovascular disease accounts for about one-third of all premature deaths (ie, age =120 mmHg), diabetes, and BMI (>=22.5 kg/m^2^): 20 mmHg higher usual SBP about doubled cardiovascular mortality (RR 2.02, 95%CI 1.88–2.18]), as did diabetes (2.15, 1.95–2.37), and 10 kg/m^2^ higher usual BMI (1.92, 1.64–2.25). RR were similar in men and in women. The association with BMI and cardiovascular mortality was almost completely attenuated following adjustment for the mediating effect of SBP. Elevated SBP (>=120 mmHg), diabetes and raised BMI (>=22.5 kg/m^2^) accounted for 27%, 14%, and 16% of cardiovascular deaths, respectively. ## Conclusions This large prospective study provides direct evidence for the effects of these major risk factors on cardiovascular mortality in Cuba. Despite comparatively low levels of these risk factors by international standards, the strength of their association with cardiovascular death means they nevertheless exert a substantial impact on premature mortality in Cuba. ## Supplementary Information The online version contains supplementary material available at 10.1186/s12889-021-10911-9.

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Author

Armas Rojas, Nurys B (author);Lacey, Ben (author);Soni, Monica (author);Charles, Shaquille (author);Carter, Jennifer (author);Varona-Pérez, Patricia (author);Burrett, Julie Ann (author);Martínez, Marcy Calderón (author);Lorenzo-Vázquez, Elba (author);Constantén, Sonia Bess (author);Taylor, Hannah (author);Sherliker, Paul (author);Rigau, José Manuel Morales (author);Ross, Stephanie (author);Massa, M. Sofia (author);López, Osvaldo Jesús Hernández (author);Islam, Nazrul (author);Morales, Miguel Ángel Martínez (author);Alomá, Ismell Alonso (author);Estupiñan, Fernando Achiong (author);González, Mayda Díaz (author);Muñoz, Noel Rosquete (author);Asencio, Marelis Cendra (author);Díaz-Diaz, Oscar (author);Iglesias-Marichal, Ileydis (author);Emberson, Jonathan (author);Peto, Richard (author);Lewington, Sarah (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)