Opening book details…
Can I read Baseline Neutrophil To Lymphocyte Ratio And Efficacy Of Sglt2 Inhibition With Empagliflozin On Cardiac Remodeling on EtoBox?
Baseline Neutrophil To Lymphocyte Ratio And Efficacy Of Sglt2 Inhibition With Empagliflozin On Cardiac Remodeling by Raj Verma; Michael Moroney; Makoto Hibino; C David Mazer; Kim Connelly; Andrew T. Yan; Adrian Quan; Hwee Teoh; Subodh Verma; Pankaj Puar is a Medicine article available to read on EtoBox.
What is Baseline Neutrophil To Lymphocyte Ratio And Efficacy Of Sglt2 Inhibition With Empagliflozin On Cardiac Remodeling about?
## Background: The neutrophil to lymphocyte ratio (NLR) is a marker of systemic inflammation and plays a critical role in the assessment and prognosis in patients with heart failure. The EMPA-HEART CardioLink-6 trial demonstrated that patients with type 2 diabetes (T2D) and coronary artery disease (CAD) treated with a sodium-glucose transport protein 2 inhibitor (SGLT2i) for 6 months experienced regression in left ventricular mass. Given this, we evaluated the relationship of baseline NLR and cardiac reverse remodelling in entire cohort of this trial. Methods: A total of 97 individuals were randomized to receive empagliflozin (10 mg/day) or placebo for six months. The primary outcome of the trial was change in left ventricular mass indexed to body surface area (LVMI) measured by cardiac magnetic resonance imaging (cMRI) from baseline to 6 months. In our analysis, the cohort was stratified above and below an NLR level of 2. To assess the treatment effect on 6-month change in NLR, we used a linear model adjusting for baseline differences in NLR (ANCOVA), that included an interaction term between the baseline NLR and treatment. To assess the treatment effect on 6-month change in LVMi
Who reads Baseline Neutrophil To Lymphocyte Ratio And Efficacy Of Sglt2 Inhibition With Empagliflozin On Cardiac Remodeling?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Raj Verma; Michael Moroney; Makoto Hibino; C David Mazer; Kim Connelly; Andrew T. Yan; Adrian Quan; Hwee Teoh; Subodh Verma; Pankaj Puar
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)