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Antioxidant and Potential Anti-inflammatory Activity of Extracts and Formulations of White Tea, Rose, and Witch Hazel on Primary Human Dermal Fibroblast Cells by Tamsyn SA Thring; Pauline Hili; Declan P Naughton is a Medicine article available to read on EtoBox.

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## Background Numerous reports have identified therapeutic roles for plants and their extracts and constituents. The aim of this study was to assess the efficacies of three plant extracts for their potential antioxidant and anti-inflammatory activity in primary human skin fibroblasts. ## Methods Aqueous extracts and formulations of white tea, witch hazel and rose were subjected to assays to measure anti-collagenase, anti-elastase, trolox equivalent and catalase activities. Skin fibroblast cells were employed to determine the effect of each extract/formulation on IL-8 release induced by the addition of hydrogen peroxide. Microscopic examination along with Neutral Red viability testing was employed to ascertain the effects of hydrogen peroxide directly on cell viability. ## Results Considerable anti-collagenase, anti-elastase, and antioxidant activities were measured for all extracts apart from the witch hazel distillate which showed no activity in the collagenase assay or in the trolox equivalence assay. All of the extracts and products tested elicited a significant decrease in the amount of IL-8 produced by fibroblast cells compared to the control (p < 0.05). None of the test sampl

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Author

Tamsyn SA Thring; Pauline Hili; Declan P Naughton

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2004-; Springer Science and Business Media LLC (ISSN 1476-9255)

Published

2011

Language

EN

Field

Medicine (Life Sciences)