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A Host-guest Drug Delivery Nanosystem for Supramolecular Chemotherapy by Hu, Xin-Yue; Gao, Jie; Chen, Fang-Yuan; Guo, Dong-Sheng is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is A Host-guest Drug Delivery Nanosystem for Supramolecular Chemotherapy about?

Supramolecular chemotherapy is currently a new strategy to improve the therapeutic efficacy as well as overcome the side effects of traditional chemotherapy. Herein, a supramolecular chemotherapy platform based on the pegylated guanidinium-modified calix[5]arene pentadodecyl ether (GC5A-12C) nanoassembly was prepared. Three commercially available antitumor drugs: oxaliplatin, methotrexate and chlorambucil, all showed strong binding to this GC5A-12C nanocarrier. The supramolecular nanodrugs achieved higher anticancer performances compared with free drugs in cell experiments. Furthermore, the cellular uptake mechanisms and efficacy are confirmed by fluorescence imaging.

Who reads A Host-guest Drug Delivery Nanosystem for Supramolecular Chemotherapy?

Author

Hu, Xin-Yue; Gao, Jie; Chen, Fang-Yuan; Guo, Dong-Sheng

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0168-3659)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)