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An observational study on the effect of S(+)‐ketamine on chronic pain versus experimental acute pain in Complex Regional Pain Syndrome type 1 patients by Marnix Sigtermans; Ingeborg Noppers; Elise Sarton; Martin Bauer; René Mooren; Erik Olofsen; Albert Dahan is a scholarly article available to read on EtoBox.

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## Abstract __Aims__ The aim of the study was to explore the analgesic effect of the __N__‐methyl‐d‐aspartate receptor (NMDAR) antagonist ketamine in acute experimental __versus__ chronic spontaneous pain in Complex Regional Pain Syndrome type 1 (CRPS‐1) patients. __Methods:__ Ten patients suffering from chronic CRPS‐1 and with a Visual Analogue pain Score (VAS) of >5 were recruited. Seven intravenous 5‐min low‐dose S(+)‐ketamine infusions with increasing doses at 20‐min intervals were applied. Spontaneous pain ratings and VAS responses to experimental heat stimuli were obtained during infusion and for 3‐h following infusion. __Results:__ CRPS pain: Ketamine produced potent analgesia with a significant VAS reduction from 6.2 ± 0.2 to 0.4 ± 0.3 cm at the end of infusion. Analgesia persisted beyond the infusion period (__VAS__ = 2.8 ± 1.0 cm at 5‐h), when measured plasma ketamine concentrations were low (<100 ng/ml). Experimental pain: Ketamine had a dose‐dependent antinociceptive effect on experimental pain that ended immediately upon the termination of infusion. __Discussion:__ The data indicate that while ketamine's effect on acute experimental pain is driven by pharmacokinetics,

Author

Marnix Sigtermans; Ingeborg Noppers; Elise Sarton; Martin Bauer; René Mooren; Erik Olofsen; Albert Dahan

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; FASEB (ISSN 1090-3801)

Published

2010

Language

EN