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Longitudinal imaging of VIP interneurons reveals sup-population specific effects of stroke that can be rescued with chemogenetic therapy by Mohamad Motaharinia; Kimberly Gerrow; Roobina Boghozian; Emily White; Sun-Eui Choi; Craig Brown is a scholarly article available to read on EtoBox.

What is Longitudinal imaging of VIP interneurons reveals sup-population specific effects of stroke that can be rescued with chemogenetic therapy about?

## Abstract Stroke profoundly disrupts cortical excitability which impedes recovery, but how it affects the function of specific inhibitory interneurons, or subpopulations therein, is poorly understood. Interneurons expressing vasoactive intestinal peptide (VIP) represent an intriguing stroke target because they can regulate cortical excitability through disinhibition. Here we chemogenetically augmented VIP interneuron excitability after stroke to show that it enhances somatosensory responses and improves recovery of paw function. Using longitudinal calcium imaging, we discovered that stroke primarily disrupts the fidelity (fraction of responsive trials) and predictability of sensory responses within a subset of highly active VIP neurons. Partial recovery of responses occurred largely within these active neurons and was not accompanied by the recruitment of minimally active neurons. Importantly, chemogenetic stimulation preserved sensory response fidelity and predictability in highly active neurons. These findings provide a new depth of understanding into how stroke and prospective therapies (chemogenetics), can influence subpopulations of inhibitory interneurons.

Author

Mohamad Motaharinia; Kimberly Gerrow; Roobina Boghozian; Emily White; Sun-Eui Choi; Craig Brown

Publisher

Research Square Platform LLC

Published

2021

Language

EN