Can I read Synthesis and DNA binding studies of bis-intercalators with a novel spiro-cyclic linker on EtoBox?

Synthesis and DNA binding studies of bis-intercalators with a novel spiro-cyclic linker by Yongjun Chu; Vincent Lynch; Brent L. Iverson is a Chemistry article available to read on EtoBox.

What is Synthesis and DNA binding studies of bis-intercalators with a novel spiro-cyclic linker about?

Threading polyintercalation has been demonstrated as a unique DNA binding mode in which a polyintercalating moiety threads back and forth through the DNA double helix. This binding topology necessitates linkers residing in both the minor and major grooves in an alternating fashion. In the present work, two novel, rigid, cis and trans oriented spiro-cyclic linkers were synthesized as potential groove binding elements in the context of threading bis-intercalation. Analysis of dissociation kinetics indicated that the cis oriented dimer has dramatically slower dissociation from poly(dGdC) and calf thymus (CT) DNA compared to the trans oriented dimer and a linear dimer control.

Who reads Synthesis and DNA binding studies of bis-intercalators with a novel spiro-cyclic linker?

Author

Yongjun Chu; Vincent Lynch; Brent L. Iverson

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4020)

Published

2006

Language

EN

Field

Chemistry (Physical Sciences)