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Mechanisms Underlying Arsenic Carcinogenesis: Hypersensitivity of Mice Exposed to Inorganic Arsenic During Gestation by Michael P Waalkes; Jie Liu; Jerrold M Ward; Bhalchandra A Diwan is a Environmental Science article available to read on EtoBox.

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Inorganic arsenic is an important human carcinogen of unknown etiology. Defining carcinogenic mechanisms is critical to assessing the human health hazard of arsenic exposure but requires appropriate model systems. It has proven difficult to induced tumors in animals with inorganic arsenic alone. Several groups have studied the carcinogenic potential of inorganic arsenic in rodents, finding it to act as co-promoter or co-carcinogen, but not as a complete carcinogen. As gestation is a time of high sensitivity to chemical carcinogenesis, we performed two in utero exposure studies with inorganic arsenic. In the first study, pregnant mice received drinking water containing sodium arsenite at 0 (control), 42.5 and 85 ppm arsenic from gestation day 8 to 18, and the offspring were observed for up to 90 weeks. As adults, male offspring developed hepatocellular carcinoma (HCC) and adrenal tumors after in utero arsenite exposure. Although liver tumors were not induced by arsenic in female offspring, they did develop lung carcinoma, ovarian tumors, and uterine and oviduct preneoplasia. In a second study, the same doses of arsenic were used and the skin tumor promoting phorbol ester, TPA, was a

Who reads Mechanisms Underlying Arsenic Carcinogenesis: Hypersensitivity of Mice Exposed to Inorganic Arsenic During Gestation?

Author

Michael P Waalkes; Jie Liu; Jerrold M Ward; Bhalchandra A Diwan

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)

Published

2004

Language

EN

Field

Environmental Science (Life Sciences)