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C-reactive Protein and Racial Differences in Type 2 Diabetes Incidence: The REGARDS Study by Kaitlyn M Peper; Boyi Guo; D Leann Long; George Howard; April P Carson; Virginia J Howard; Suzanne E Judd; Neil A Zakai; Andrea Cherrington; Mary Cushman; Timothy B Plante is a Medicine article available to read on EtoBox.
What is C-reactive Protein and Racial Differences in Type 2 Diabetes Incidence: The REGARDS Study about?
## Abstract ## Context Black adults experience more type 2 diabetes mellitus and higher inflammatory markers, including C-reactive protein (CRP), than White adults. Inflammatory markers are associated with risk of incident diabetes but the impact of inflammation on racial differences in incident diabetes is unknown. ## Objective We assessed whether CRP mediated the Black–White incident diabetes disparity. ## Methods The REasons for Geographic And Racial Differences in Stroke (REGARDS) study enrolled 30 239 US Black and White adults aged ≥45 years in 2003-2007 with a second visit approximately 10 years later. Among participants without baseline diabetes, adjusted sex- and race-stratified risk ratios for incident diabetes at the second visit by CRP level were calculated using modified Poisson regression. Inverse odds weighting estimated the percent mediation of the racial disparity by CRP. ## Results Of 11 073 participants without baseline diabetes (33% Black, 67% White), 1389 (12.5%) developed diabetes. Black participants had higher CRP at baseline and greater incident diabetes than White participants. Relative to CRP < 3 mg/L, CRP ≥ 3 mg/L was associated with greater risk of diabet
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- Author
- Kaitlyn M Peper; Boyi Guo; D Leann Long; George Howard; April P Carson; Virginia J Howard; Suzanne E Judd; Neil A Zakai; Andrea Cherrington; Mary Cushman; Timothy B Plante
- Publisher
- The Endocrine Society
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)