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This study presents a mathematical model that quantitatively describes the relationship between Gibbs-Donnan equilibrium, body fluid osmolality, and plasma sodium concentration. It highlights how negatively charged proteins in plasma influence the distribution of ions and osmolality across fluid compartments, resulting in a higher plasma osmolality compared to interstitial and intracellular fluids. The model provides insights into how changes in plasma protein concentration can affect sodium levels and osmo
- Author
- Miko Piers
- Language
- EN