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What is Curcumin-Induced DNA Damage in HepG2 Cells about?

Curcumin is a natural compound found in turmeric that has anticarcinogenic properties. This study examined the effects of curcumin on mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) in human liver cells. The researchers found that curcumin induced dose-dependent DNA damage in both mtDNA and nDNA as measured by quantitative PCR and immunostaining. Comet assays also showed nuclear DNA fragmentation after curcumin treatment. The DNA damage was linked to increased reactive oxygen species and lipid peroxidation

Author

cat

Language

EN