Can I read Immune Microenvironment in Different Molecular Subtypes of Ductal Breast Carcinoma on EtoBox?

Immune Microenvironment in Different Molecular Subtypes of Ductal Breast Carcinoma by Mona Sadeghalvad; Hamid-Reza Mohammadi-Motlagh; Nima Rezaei is a Medicine article available to read on EtoBox.

What is Immune Microenvironment in Different Molecular Subtypes of Ductal Breast Carcinoma about?

Purpose Ductal breast carcinoma as a heterogeneous disease has different molecular subtypes associated with clinical prognosis and patients' survival. The role of immune system as a consistent part of the tumor microenvironment (TME) has been documented in progression of ductal breast carcinoma. Here, we aimed to describe the important immune cells and the immune system-associated molecules in Ductal Carcinoma In situ (DCIS) and Invasive Ductal Carcinoma (IDC) with special emphasis on their associations with different molecular subtypes and patients' prognosis. ## Results The immune cells have a dual role in breast cancer (BC) microenvironment depending on the molecular subtype or tumor grade. These cells with different frequencies are present in the TME of DCIS and IDC. The presence of regulatory cells including Tregs, MDSC, Th2, Th17, M2 macrophages, HLADR -T cells, and Tγδ cells is related to more immunosuppressive microenvironment, especially in ER -and TN subtypes. In contrast, NK cells, CTL, Th, and Tfh cells are associated to the anti-tumor activity. These cells are higher in ER + BC, although in other subtypes such as TN or HER2 + are associated with a favorable prognosis.

Who reads Immune Microenvironment in Different Molecular Subtypes of Ductal Breast Carcinoma?

Author

Mona Sadeghalvad; Hamid-Reza Mohammadi-Motlagh; Nima Rezaei

Publisher

Springer Science and Business Media LLC

Published

2020

Language

EN

Field

Medicine (Health Sciences)