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Biomarkers for Microvascular Proteins Detection: Blood–Brain Barrier Injury and Damage Measurement by Pavani Sayana; Jean Pierre Oses; Tatiana Barichello; Vijayasree V. Giridharan is a book available to read on EtoBox.

What is Biomarkers for Microvascular Proteins Detection: Blood–Brain Barrier Injury and Damage Measurement about?

Blood-brain barrier (BBB) is a highly selective semipermeable membrane with tight junctions formed from closely wedged epithelial cells and is the principal regulator of exchange of materials between the blood and the brain, simultaneously protecting it from the systemic insults. Any impairment in the functional coordinated effort or formation of the components of the BBB neurovascular bundle may lead to neurological disturbances from entry of extraneous elements. The BBB disruption causes an imbalance in tight junction proteins, adherens junction proteins, matrix metalloproteinases, cell adhesion molecules, and a myriad of neuroinflammatory proteins. Therefore, the modalities, which can enable the accurate detection of BBB breach in advance via protein biomarker assay to underpin targeted medicines, are of growing priority. In this chapter, we will summarize the BBB pathology measurement methods used in the detection of microvascular protein biomarkers such as Western blot, immunohistochemistry (IHC), enzyme-linked immunosorbent assay (ELISA), and real-time polymerase chain reaction (RT-PCR). In addition, we also emphasize on the BBB genomics and the method used to detect function

Author

Pavani Sayana; Jean Pierre Oses; Tatiana Barichello; Vijayasree V. Giridharan

Publisher

Springer New York

Published

2018

Language

EN

ISBN

9781493989454

Subjects

Medical, Medicine