Can I read Deconjugated‐Ketone‐Derived Dienolates in Remote, Stereocontrolled, Aromative aza ‐Diels‐Alder Cycloaddition on EtoBox?

Deconjugated‐Ketone‐Derived Dienolates in Remote, Stereocontrolled, Aromative aza ‐Diels‐Alder Cycloaddition by Frankowski, Sebastian; SkrzyÅska, Anna; SieroÅ, LesÅaw; Albrecht, Åukasz is a Chemistry article available to read on EtoBox.

What is Deconjugated‐Ketone‐Derived Dienolates in Remote, Stereocontrolled, Aromative aza ‐Diels‐Alder Cycloaddition about?

## Abstract In the manuscript, the application of β,γ‐unsaturated ketones as precursors of electron‐rich dienophiles in the organocatalytic, aromative inverse‐electron‐demand hetero‐Diels‐Alder cycloaddition is described. The reaction leads to the formation of biologically relevant benzofuran derivatives bearing additional tetrahydropyridine ring. The reaction is fully site‐selective and occurs preferentially at the distal double bond of the dienolate intermediate. Given the absolute configuration assignment a step‐wise mechanism has been proposed and the formation of aromatic benzofuran ring indicated as the driving force of the cascade. magnified image

Who reads Deconjugated‐Ketone‐Derived Dienolates in Remote, Stereocontrolled, Aromative aza ‐Diels‐Alder Cycloaddition?

Author

Frankowski, Sebastian; SkrzyÅska, Anna; SieroÅ, LesÅaw; Albrecht, Åukasz

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley - V C H Verlag GmbbH & Co.; Wiley (ISSN 1615-4150)

Published

2020

Language

EN

Field

Chemistry (Physical Sciences)