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White matter microstructure in children and adolescents with ADHD by Michael Connaughton; Robert Whelan; Erik O'Hanlon; Jane McGrath is a Medicine article available to read on EtoBox.

What is White matter microstructure in children and adolescents with ADHD about?

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. Advances in diffusion magnetic resonance imaging (MRI) acquisition sequences and analytic techniques have led to growing body of evidence that abnormal white matter microstructure is a core pathophysiological feature of ADHD. This systematic review provides a qualitative assessment of research investigating microstructural organisation of white matter amongst children and adolescents with ADHD. This review included 46 studies in total, encompassing multiple diffusion MRI imaging techniques and analytic approaches, including whole-brain, region of interest and connectomic analyses. Whole-brain and region of interest analyses described atypical organisation of white matter microstructure in several white matter tracts: most notably in frontostriatal tracts, corpus callosum, superior longitudinal fasciculus, cingulum bundle, thalamic radiations, internal capsule and corona radiata. Connectomic analyses, including graph theory approaches, demonstrated global underconnectivity in connections between functionally specialised networks. Although some studies reported significant correlations between at

Who reads White matter microstructure in children and adolescents with ADHD?

Author

Michael Connaughton; Robert Whelan; Erik O'Hanlon; Jane McGrath

Published

2022

Language

EN

Field

Medicine (Health Sciences)