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Can I read Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-Positive antibacterial activity on EtoBox?
Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-Positive antibacterial activity by Richard L Jarvest; John M Berge; Murray J Brown; Pamela Brown; John S Elder; Andrew K Forrest; C.S.V Houge-Frydrych; Peter J O'Hanlon; David J McNair; Stephen Rittenhouse; Robert J Sheppard is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-Positive antibacterial activity about?
Optimisation of the left-hand-side aryl moiety of a file compound screening hit against Staphylococcus aureus methionyl tRNA synthetase led to the identification of a series of potent nanomolar inhibitors. The best compounds showed excellent antibacterial activity against staphylococcal and enterococcal pathogens, including strains resistant to clinical antibiotics.
Who reads Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-Positive antibacterial activity?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Richard L Jarvest; John M Berge; Murray J Brown; Pamela Brown; John S Elder; Andrew K Forrest; C.S.V Houge-Frydrych; Peter J O'Hanlon; David J McNair; Stephen Rittenhouse; Robert J Sheppard
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2003
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)