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Application of Bone Collagen Matrix combined with HUC-MSCs for Alveolar Process Cleft in a Rabbit Model by Xue-Cheng Sun; Hu Wang; Dan Zhang; Jian-Hui Li; Li-Qiang Yin; Yu-Fang Yan; Xu Ma; Hong-Fei Xia is a scholarly article available to read on EtoBox.

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## Abstract Background: Most materials used clinically for filling severe bone defects lack the ability to induce bone regeneration or low bone conversion rate, therefore, their therapeutic effects are limited. Human umbilical cord mesenchymal stem cells (HUC-MSCs) have good osteoinduction. The mechanism of heterogeneous bone collagen matrix combined with HUC-MSCs in repairing bone defects of alveolar process cleft is still unclear.Methods: Here, a rabbit alveolar process cleft model was established to evaluate the repair effect and molecular mechanism of bone collagen matrix and its combination with HUC-MSCs on critical-sized bone defects in the alveolar process. We randomly divided 48 young Japanese white rabbits (JWRs) into normal, control, material and MSCs groups. The alveolar process cleft model was established by removing the bone of equal volume at the left maxillary. Bone collagen matrix combined with HUC-MSCs that were then implanted in the defect area. X-ray analysis and blood analysis were analyzed 3 months after surgery. Skull tissues were collected for micro-focus computerized tomography (micro-CT) analysis and histochemical staining. The above experiment was repeated

Author

Xue-Cheng Sun; Hu Wang; Dan Zhang; Jian-Hui Li; Li-Qiang Yin; Yu-Fang Yan; Xu Ma; Hong-Fei Xia

Publisher

Research Square Platform LLC

Published

2021

Language

EN