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Lessons to Be Learnt from Organophosphorus Pesticide Poisoning for the Treatment of Nerve Agent Poisoning by H. Thiermann; L. Szinicz; P. Eyer; N. Felgenhauer; T. Zilker; F. Worek is a Environmental Science article available to read on EtoBox.

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The increasing threat of nerve agent use for terrorist purposes against civilian and military population calls for effective therapeutic preparedness. At present, administration of atropine and an oxime are recommended, although effectiveness of this treatment is not proved in clinical trials. Here, monitoring of intoxications with organophosphorus (OP) pesticides may be of help, as their actions are closely related to those of nerve agents and intoxication and therapy follow the same principles. To this end, the clinical course of poisoning and the effectiveness of antidotal therapy were investigated in patients requiring artificial ventilation being treated with atropine and obidoxime. However, poisoning with OP pesticides shows extremely heterogeneous pictures of cholinergic crisis frequently associated with clinical complications. To achieve valuable information for the therapy of nerve agent poisoning, cases resembling situations in nerve agent poisoning had to be extracted: (a) intoxication with OPs forming reactivatable OP-AChEcomplexes with short persistence of the OP in the body resembling inhalational sarin intoxication; (b) intoxication with OPs resulting rapidly in an a

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Author

H. Thiermann; L. Szinicz; P. Eyer; N. Felgenhauer; T. Zilker; F. Worek

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)

Published

2007

Language

EN

Field

Environmental Science (Life Sciences)