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Study on mechanism of matrine in treatment of COVID-19 combined with liver injury by network pharmacology and molecular docking technology by Fangzhou Liu; Yuanbai Li; Yang Yang; Meng Li; Yu Du; Yiying Zhang; Jing Wang; Yujing Shi is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is Study on mechanism of matrine in treatment of COVID-19 combined with liver injury by network pharmacology and molecular docking technology about?
The aim of the present study was to investigate the pharmacological mechanism of matrine in treatment of COVID-19 combined with liver injury. Potential targets related to matrine, COVID-19 and liver injury were identified from several databases. We constructed PPI network and screened the core targets according to the degree value. Then, GO and KEGG enrichment were carried out. Molecular docking technology was used to verify the affinity between matrine and the crystal structure of core target protein. Finally, real-time RT-PCR was used to detect the effects of matrine on hub gene expression in liver tissue of liver injury mice and lung tissue of lung injury mice to further confirm the results of network pharmacological analysis. The results show that six core targets including AKT1, TP53, TNF, IL6, BCL2L1 and ATM were identified. The potential therapeutic mechanism of matrine on COVID-19 combined with liver injury is closely related to regulate antiviral process, improve immune system and regulate the level of inflammatory factors. Molecular docking showed that matrine could spontaneously bind to the receptor protein and had strong binding force. Real-time RT-PCR demonstrated that
Who reads Study on mechanism of matrine in treatment of COVID-19 combined with liver injury by network pharmacology and molecular docking technology?
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- Fangzhou Liu; Yuanbai Li; Yang Yang; Meng Li; Yu Du; Yiying Zhang; Jing Wang; Yujing Shi
- Publisher
- Informa UK Limited
- Published
- 2021
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)