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Tralokinumab treatment improves the skin microbiota by increasing the microbial diversity in adults with moderate-to-severe atopic dermatitis: Analysis of microbial diversity in ECZTRA 1, a randomized controlled trial by Lisa A. Beck; Thomas Bieber; Stephan Weidinger; Marie Tauber; Hidehisa Saeki; Alan D. Irvine; Lawrence F. Eichenfield; Thomas Werfel; Petra Arlert; Li Jiang; Mads Røpke; Amy S. Paller is a Medicine article available to read on EtoBox.

What is Tralokinumab treatment improves the skin microbiota by increasing the microbial diversity in adults with moderate-to-severe atopic dermatitis: Analysis of microbial diversity in ECZTRA 1, a randomized controlled trial about?

Background Atopic dermatitis (AD) is characterized by microbial dysbiosis, immune dysregulation, and an impaired skin barrier. Microbial dysbiosis in AD involves a reduction in diversity primarily driven by an increased abundance of Staphylococcus aureus. Tralokinumab, an approved treatment for adults with moderate-to-severe AD, improves the skin barrier and immune abnormalities by specifically targeting the interleukin 13 cytokine, but its impact on the skin microbiome is unknown. Objective To investigate how tralokinumab affects the skin microbiome by examining the lesional skin of adults with moderate-to-severe AD from the phase 3 ECZTRA 1 trial (NCT03131648). Methods Microbiome profiling, S aureus abundance, and biomarker data were assessed in a subset of ECZTRA 1 participants (S aureus abundance at baseline and week 16; microbiome profiling at baseline, and week 8/16; and serum sampling before dose and week 4/8/16/28/52). Results Tralokinumab treatment led to increased microbial diversity, reduced S aureus abundance, and increased abundance of the commensal coagulase-negative Staphylococci. Limitations Limitations include a lack of S aureus abundance data at week 8, sampling s

Who reads Tralokinumab treatment improves the skin microbiota by increasing the microbial diversity in adults with moderate-to-severe atopic dermatitis: Analysis of microbial diversity in ECZTRA 1, a randomized controlled trial?

Author

Lisa A. Beck; Thomas Bieber; Stephan Weidinger; Marie Tauber; Hidehisa Saeki; Alan D. Irvine; Lawrence F. Eichenfield; Thomas Werfel; Petra Arlert; Li Jiang; Mads Røpke; Amy S. Paller

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)