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Glucocorticoids and Hippocampal Structure and Function in PTSD by Philip R. Szeszko; Amy Lehrner; Rachel Yehuda is a Psychology article available to read on EtoBox.

What is Glucocorticoids and Hippocampal Structure and Function in PTSD about?

This review examines the putative link between glucocorticoid and hippocampal abnormalities in posttraumatic stress disorder (PTSD). Increased glucocorticoid receptor (GR) sensitivity in PTSD may permit enhanced negative feedback inhibition of cortisol at the pituitary, hypothalamus, or other brain regions comprising the hypothalamicpituitary-adrenal (HPA) axis and would be expected to affect other physiological systems that are regulated by glucocorticoids. Molecular and transcriptional studies of cortisol are consistent with the hypothesis that cortisol actions may be amplified in PTSD as a result of enhanced GR sensitivity in monocytes and some brain regions, although cortisol levels themselves are unchanged and oftentimes lower than normal. Concurrently, magnetic resonance imaging studies have demonstrated that individuals with PTSD have smaller hippocampal volume than individuals without PTSD. Initial hypotheses regarding the mechanism underlying hippocampal alterations in PTSD focused on elevated glucocorticoid levels in combination with extreme stress as the primary cause, but this explanation has not been well supported in human studies. Lack of data from neuroimaging studi

Who reads Glucocorticoids and Hippocampal Structure and Function in PTSD?

Author

Philip R. Szeszko; Amy Lehrner; Rachel Yehuda

Publisher

Informa plc; Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins; Lippincott Williams & Wilkins Ltd.; Ovid Technologies (Wolters Kluwer Health); Informa UK Limited (ISSN 1067-3229)

Published

2018

Language

EN

Field

Psychology (Social Sciences)