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Protective effects of antioxidants on micronuclei induced by irradiated 9-fluorenone/N,N-dimethyl-p-toluidine in CHO cells by Yi-Ching Li; Fu-Mei Huang; Shiuan-Shinn Lee; Ruey-Hseng Lin; Ming-Yung Chou; Yu-Chao Chang is a Medicine article available to read on EtoBox.

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## Abstract 9‐Fluorenone (9F), the aromatic photosensitizer, is widely used as an initiator in visible‐light (VL) cured resin systems. There is growing concern that 9F may produce genetic damage by inducing mutation. In this study, 9F in the presence or absence of reducing agent __N__,__N__‐dimethyl‐__p__‐toluidine (DMT) with or without VL irradiation was analyzed for the induction of chromosomal aberrations indicated by micronuclei (MN) induced in CHO cells. Our data demonstrated that a dose‐related increase in the frequency of MN and prolonged cell cycles in 9F with or without DMT in the presence or absence of VL irradiation (__p__ 9F/DMT = 9F + VL > 9F. To determine whether oxidative stress could modulate MN induced by 9F/DMT with or without VL irradiation in CHO cells, cells were pretreated with __N__‐acetyl‐L‐cysteine (NAC), ascorbic acid, and α‐tocopherol. The pretreatment with antioxidants could diminish not only the prolonged cell cycle but also the decreased frequency of MN which is induced by 9F with or without DMT in the presence or absence of VL irradiation in CHO cells (__p__ < 0.05). Our findings provide the evidences for the induction of MN by 9F in the presence or

Who reads Protective effects of antioxidants on micronuclei induced by irradiated 9-fluorenone/N,N-dimethyl-p-toluidine in CHO cells?

Author

Yi-Ching Li; Fu-Mei Huang; Shiuan-Shinn Lee; Ruey-Hseng Lin; Ming-Yung Chou; Yu-Chao Chang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1552-4973)

Published

2007

Language

EN

Field

Medicine (Health Sciences)