Can I read Population Pharmacokinetic Analysis of Tacrolimus Early After Pediatric Liver Transplantation on EtoBox?

Population Pharmacokinetic Analysis of Tacrolimus Early After Pediatric Liver Transplantation by Flora T. Musuamba; Vanessa Guy-Viterbo; Raymond Reding; Roger K. Verbeeck; Pierre Wallemacq is a Medicine article available to read on EtoBox.

What is Population Pharmacokinetic Analysis of Tacrolimus Early After Pediatric Liver Transplantation about?

## Background: Tacrolimus (tac) pharmacokinetics (pks) show considerable unexplained variability, particularly in the early period after transplantation. therefore, tac is a good candidate for therapeutic drug monitoring. the main objective of the present work was to propose a robust pk model for tac in the early period after transplantation, with the final goal to provide practitioners with a tool for dose individualization in pediatric patients. ## Methods: Tac concentration data were obtained from 82 pediatric liver allograft recipients during the first 2 weeks after transplantation. previously published models, and a model recently developed by our group for pediatrics early after pediatric liver transplantation, were fitted to the data and their predictive performance compared with the performances of a model developed using the data from 82 pediatric patients. ## Results: During the data-driven analysis, the pks of tac were best described by a 1-compartment model with time-varying first order elimination. apparent volume of distribution and blood clearance estimates were 283 l and 10 l/h, respectively. the absorption was also considered to be a first order process, with a fir

Who reads Population Pharmacokinetic Analysis of Tacrolimus Early After Pediatric Liver Transplantation?

Author

Flora T. Musuamba; Vanessa Guy-Viterbo; Raymond Reding; Roger K. Verbeeck; Pierre Wallemacq

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2013

Language

EN

Field

Medicine (Health Sciences)