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Can I read Diagnostic work-up of inflammatory bowel disease in children: The role of calprotectin assay on EtoBox?
Diagnostic work-up of inflammatory bowel disease in children: The role of calprotectin assay by A. Diamanti; F. Panetta; M. S. Basso; A. Forgione; F. Colistro; F. Bracci; B. Papadatou; P. Francalanci; F. Torroni; D. Knafelz; F. Fina; M. Castro is a Medicine article available to read on EtoBox.
What is Diagnostic work-up of inflammatory bowel disease in children: The role of calprotectin assay about?
Background: Some reports highlight the potential application of fecal calprotectin as a direct biomarker of intestinal inflammation and, therefore, as support in choosing candidates for endoscopy. The value of 100 lg/g was recently assumed as the best cutoff for this assay. The purpose of this study was to assess the diagnostic precision of the fecal calprotectin assay, compared to histology, as a stool-screening biomarker for inflammatory bowel disease (IBD) among a group of prospectively identified patients referred for recurrent abdominal pain and altered bowel habits. Methods: Between 1999 and 2007 we prospectively evaluated the calprotectin assay in a cohort of patients with recurrent abdominal pain and altered bowel habits associated or not with other symptoms suggestive of IBD. All patients suspected of IBD, according to Rome and Porto criteria, provided stool specimens for the calprotectin assay and subsequently underwent endoscopic procedures. Results: Compared to histology, the cutoff of 100 lg/g reached a sensitivity and specificity of 100% and 68%, respectively, and a likelihood ratio (LR) of 3.1. The cutoff value of 160 lg/g, however, in our series produced the best jo
Who reads Diagnostic work-up of inflammatory bowel disease in children: The role of calprotectin assay?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- A. Diamanti; F. Panetta; M. S. Basso; A. Forgione; F. Colistro; F. Bracci; B. Papadatou; P. Francalanci; F. Torroni; D. Knafelz; F. Fina; M. Castro
- Publisher
- John Wiley and Sons; Oxford University Press; Oxford University Press (OUP) (ISSN 1078-0998)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)