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Antioxidant Deficiency Following Clam Enterocystoplasty by J.W. BARRINGTON; A. JONES; D. JAMES; S. SMITH; T.P. STEPHENSON is a Medicine article available to read on EtoBox.

What is Antioxidant Deficiency Following Clam Enterocystoplasty about?

## Objective To assess whether there is a reduction in serum antioxidant activity in patients who have undergone a clam enterocystoplasty procedure. ## Patients and methods Serum glutathione peroxidase (GPase) activity was measured in 20 patients who had undergone clam enterocystoplasty. Serum selenium concentration was also measured in 62 similar patients and compared with 56 healthy controls and 44 patients with a neuropathic bladder, mainly patients with spinal cord injuries who had not undergone surgery. ## Results GPase activity correlated well with serum selenium measurement. There was a significant reduction (__P__<0.001) in serum selenium level in young (<50 years old) non‐neuropathic bladder patients following clam enterocystoplasty. This reduction in serum selenium was similar to that found in both unoperated patients with a neuropathic bladder (who are known to have an increased risk of developing bladder cancer) and those patients with a neuropathic bladder who had undergone augmentation. This reduction was not related to urinary tract infection nor the time since surgery. ## Conclusion A reduction in serum selenium has been shown to increase susceptibility to bladder c

Who reads Antioxidant Deficiency Following Clam Enterocystoplasty?

Author

J.W. BARRINGTON; A. JONES; D. JAMES; S. SMITH; T.P. STEPHENSON

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1464-4096)

Published

1997

Language

EN

Field

Medicine (Health Sciences)