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Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: Chromosomes 4, 7, 9, 18, 19, 20, and 21 by Virginia L. Willour; Peter P. Zandi; Yuqing Huo; Tyra L. Diggs; Jennifer L. Chellis; Dean F. MacKinnon; Sylvia G. Simpson; Francis J. McMahon; James B. Potash; Elliot S. Gershon; Theodore Reich; Tatiana Foroud; John I. Nurnberger; J. Raymond DePaulo; Melvin G. McInnis is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: Chromosomes 4, 7, 9, 18, 19, 20, and 21 about?
## Abstract The NIMH genetics initiative on bipolar disorder was established to collect uniformly ascertained bipolar pedigrees for genetic studies. In 1997, the four participating sites published a genome scan on the initial set of 97 bipolar pedigrees. Fifty‐six additional bipolar pedigrees have now been ascertained and evaluated. This replication pedigree set contains 354 genotyped subjects, including 139 bipolar I (BPI) subjects, five schizoaffective bipolar type SA/BP subjects, 41 bipolar II (BPII) subjects, and 43 recurrent unipolar (RUP) depression subjects. Our site has recently genotyped the replication study bipolar pedigrees using 107 microsatellite markers from chromosomes 4, 7, 9, 18, 19, 20, and 21. We are now reporting parametric and nonparametric linkage results from this effort. Multipoint nonparametric linkage analysis produced three candidate regions with allele sharing LOD scores ≥ 1.0. The linkage signal on 4q35 peaked between markers D4S3335 and D4S2390 with an allele sharing LOD score of 2.49. This finding exceeds standard criteria for suggestive linkage. Two additional loci approach suggestive linkage levels: the 4q32 finding had its maximum near marker D4S1
Who reads Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: Chromosomes 4, 7, 9, 18, 19, 20, and 21?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Virginia L. Willour; Peter P. Zandi; Yuqing Huo; Tyra L. Diggs; Jennifer L. Chellis; Dean F. MacKinnon; Sylvia G. Simpson; Francis J. McMahon; James B. Potash; Elliot S. Gershon; Theodore Reich; Tatiana Foroud; John I. Nurnberger; J. Raymond DePaulo; Melvin G. McInnis
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0148-7299)
- Published
- 2003
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)