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Use of overnight metyrapone test in suspected secondary adrenal insufficiency: A retrospective single centre‐study by Jasmine Saini; Raul Gregg Garcia; Justine Herndon; Dana Erickson; Lucinda Gruber; Irina Bancos is a Medicine article available to read on EtoBox.

What is Use of overnight metyrapone test in suspected secondary adrenal insufficiency: A retrospective single centre‐study about?

## Abstract ## Objective Overnight metyrapone test (OMT) is a dynamic test used to diagnose secondary adrenal insufficiency (SAI). Data on OMT use and its safety are scarce. We aimed to describe the indications and safety of outpatient OMT and compare OMT to the cosyntropin stimulation test (CST). ## Design Single‐centre retrospective study of adult patients undergoing OMT between 1 April 2018 and 27 January 2023. ## Measurements OMT‐related adverse events, post‐OMT diagnosis of SAI, and OMT comparison to CST. ## Results OMT was performed in 114 patients (81, 71% women) at a median age of 48 (interquartile range 37–58). The pretest probability for SAI was low in 52 (46%) patients, moderate in 48 (42%) patients and high in 14 (12%) patients. Adverse events were reported in 7 (6.1%) patients and were mild except for one hospitalization. No baseline or OMT‐related factors were associated with the development of adverse events. Prevalence of the OMT‐based SAI diagnosis was 26 (23%) and 47 (46%) using 11‐deoxycortisol cutoff <7 and <10 mcg/dL, respectively. Higher pretest probability was associated with the OMT‐based diagnosis of SAI. Post‐OMT 11‐deoxycortisol cutoff of 10 mcg/dL was us

Who reads Use of overnight metyrapone test in suspected secondary adrenal insufficiency: A retrospective single centre‐study?

Author

Jasmine Saini; Raul Gregg Garcia; Justine Herndon; Dana Erickson; Lucinda Gruber; Irina Bancos

Publisher

Wiley

Published

2023

Field

Medicine (Health Sciences)