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Bioinformatics-based Analysis of Potential Candidates Chromatin Regulators for Immune Infiltration in Osteoarthritis by Weiwei Wang; Zhixue Ou; Jianlan Peng; Ning Wang; Yi Zhou is a Medicine article available to read on EtoBox.

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## Abstract ## Background Through the bioinformatics analysis to screen out the potential chromatin regulators (CRs) under the immune infiltration of osteoarthritis (OA), thus providing some theoretical support for future studies of epigenetic mechanisms under OA immune infiltration. ## Methods By integrating CRs and the OA gene expression matrix, we performed weighted gene co-expression network analysis (WGCNA), differential analysis, and further screened Hub genes by protein-protein interaction (PPI) analysis. Using the OA gene expression matrix, immune infiltration extraction and quantification were performed to analyze the correlations and differences between immune infiltrating cells and their functions. By virtue of these Hub genes, Hub gene association analysis was completed and their upstream miRNAs were predicted by the FunRich software. Moreover, a risk model was established to analyze the risk probability of associated CRs in OA, and the confidence of the results was validated by the validation dataset. ## Results This research acquired a total of 32 overlapping genes, and 10 Hub genes were further identified. The strongest positive correlation between dendritic cells an

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Author

Weiwei Wang; Zhixue Ou; Jianlan Peng; Ning Wang; Yi Zhou

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)