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Quantification of CCI-103F labeling heterogeneity in canine solid tumors by J.Mark Cline; Gary L. Rosner; James A. Raleigh; Donald E. Thrall is a Medicine article available to read on EtoBox.
What is Quantification of CCI-103F labeling heterogeneity in canine solid tumors about?
## Purpose: The purposes of this study were to assess sources of variation in the distribution of nitroimidazole-labeled hypoxic cells in canine tumors and to quantify the reliability of estimating overall nitroimidazole-labeled area fraction from biopsies. ## Methods and materials: Hypoxic cells were labeled in 24 canine tumors by immunostaining of the nitroimidazole hypoxia marker cci-103f. in tumors with a volume < 100 cm3, each cubic centimeter of tumor was examined; in larger tumors 100 randomly selected 1 cm3 samples were examined. these data were used to estimate the overall cci-103f-labeled area fraction in the tumor. a variance components model was used to quantify intertumoral, intratumoral, and within slide (residual) sources of variation. the ability to estimate intratumoral cci-103f-labeled area fraction based on information obtained from biopsies was assessed by randomly selecting two or four samples from the dataset for each tumor and comparing the mean cci-103f-labeled area fraction from this limited sample to the labeled area fraction based on each cubic centimeter; this simulation process was repeated 1000 times. ## Results: Intratumoral (27% of total) and intertu
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- Author
- J.Mark Cline; Gary L. Rosner; James A. Raleigh; Donald E. Thrall
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)