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Fra‐1 targets the AP‐1 site/2G single nucleotide polymorphism (ETS site) in the MMP‐1 promoter by Grant B. Tower; Charles I. Coon; Karine Belguise; Dany Chalbos; Constance E. Brinckerhoff is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The matrix metalloproteinase (MMP) family degrades the extracellular matrix. One member of this family, MMP‐1, initiates the breakdown of interstitial collagens. The expression of MMP‐1 is controlled by the mitogen activated protein kinase (MAPK) pathway(s) via the activity of activator protein‐1 (AP‐1) and polyoma enhancing activity‐3/E26 virus (PEA3/ETS) transcription factors through consensus binding sites present in the promoter. Another ETS site in the MMP‐1 promoter is created at −1607 bp by a single nucleotide polymorphism (SNP), which contains two guanines (5′‐GGAT‐3′; ‘2G SNP’), rather one guanine (5′‐GAT‐3′; ‘1G SNP’), adjacent to an AP‐1 binding site at −1602 bp. The 2G SNP displays greater transcriptional activity than the 1G SNP, and AP‐1 and Ets families of transcription factors cooperate to increase transcription. The 2G SNP has been linked to the incidence and the progression of several cancer**s** and is also associated with non‐neoplastic diseases; although the underlying mechanism(s) has yet to be elucidated. In this study we demonstrate that the expression of Fos‐like region antigen (Fra‐1), an AP‐1 transcription factor component that also correlates strongly wi

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Author

Grant B. Tower; Charles I. Coon; Karine Belguise; Dany Chalbos; Constance E. Brinckerhoff

Publisher

John Wiley and Sons; Springer; Wiley (Blackwell Publishing); Springer-Verlag; Blackwell Publishing Inc.; Springer Verlag; Wiley; Springer Science and Business Media LLC (ISSN 1432-1327)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Physical Sciences)