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A High Throughput Luminescent Assay For Glycogen Synthase Kinase-3 Inhibitors by Alexandru Sava is a document available to read on EtoBox.
What is A High Throughput Luminescent Assay For Glycogen Synthase Kinase-3 Inhibitors about?
The document describes the development of a high throughput luminescent assay for screening glycogen synthase kinase-3 (GSK-3) inhibitors using the Kinase-Glo™ system. The assay was optimized for robustness and sensitivity, successfully screening 55,000 compounds and identifying five classes of potent GSK-3 inhibitors. This method is nonradioactive and suitable for high throughput screening, addressing limitations of existing kinase assays.
- Author
- Alexandru Sava
- Language
- EN