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Distinct expression of CDX2 and GATA4/5, development-related genes, in human gastric cancer cell lines by Yun-Qing Bai; Yoshimitsu Akiyama; Hiromi Nagasaki; Osmar Kenji Yagi; Yoko Kikuchi; Naoya Saito; Kimiya Takeshita; Takehisa Iwai; Yasuhito Yuasa is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Distinct expression of CDX2 and GATA4/5, development-related genes, in human gastric cancer cell lines about?
CDX2 is a tumor-suppressor homeobox gene involved in colon carcinogenesis, but its role in gastric cancer is unknown. Although GATA4, -5 and, -6 transcription factors have distinct functions in the regulation of gastrointestinal epithelial cell differentiation, there have been no reports regarding GATA4/5/6 alterations in gastrointestinal carcinomas. By using a semiquantitative reverse transcription-polymerase chain reaction assay, we studied the expression of gut development-related genes CDX2/1 and GATA4/5/6 in 11 human gastric cancer cell lines. The expression of CDX2 appeared to progressively decrease with the transition from well differentiated to poorly differentiated cancer cell lines. CDX1 was below detectable levels in all cell lines. The expression of GATA4 and GATA5 was undetectable in four and six cell lines, respectively, whereas the majority of the cell lines expressed GATA6 abundantly. These results suggest that CDX2 and GATA4/5 may be associated with the carcinogenesis of the stomach. Mol. Carcinog. 28:184-188, 2000.
Who reads Distinct expression of CDX2 and GATA4/5, development-related genes, in human gastric cancer cell lines?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yun-Qing Bai; Yoshimitsu Akiyama; Hiromi Nagasaki; Osmar Kenji Yagi; Yoko Kikuchi; Naoya Saito; Kimiya Takeshita; Takehisa Iwai; Yasuhito Yuasa
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)
- Published
- 2000
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)