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Synthesis, molecular modeling studies and selective inhibitory activity against MAO of N1-propanoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives by Franco Chimenti; Rossella Fioravanti; Adriana Bolasco; Fedele Manna; Paola Chimenti; Daniela Secci; Francesca Rossi; Paola Turini; Francesco Ortuso; Stefano Alcaro; Maria Cristina Cardia is a Chemistry article available to read on EtoBox.

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A series of N1-propanoyl-3,5-diphenyl-4,5-dihydro-(1H )-pyrazole derivatives were synthesized and assayed as inhibitors of MAO-A and MAO-B isoforms. Most of the tested compounds showed inhibitory activity with micromolar values and MAO-A selectivity. In addition a computational work was carried out on the most selective compound 3b to highlight the most relevant interactions in the mechanism of recognition within both the MAO-A and the MAO-B enzyme active sites.

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Author

Franco Chimenti; Rossella Fioravanti; Adriana Bolasco; Fedele Manna; Paola Chimenti; Daniela Secci; Francesca Rossi; Paola Turini; Francesco Ortuso; Stefano Alcaro; Maria Cristina Cardia

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)

Published

2008

Language

EN

Field

Chemistry (Physical Sciences)