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Perspectives of Future Lung Toxicology Studies Using Human Pluripotent Stem Cells by Atsushi Masui; Toyohiro Hirai; Shimpei Gotoh is a Environmental Science article available to read on EtoBox.

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The absence of in vitro platforms for human pulmonary toxicology studies is becoming an increasingly serious concern. The respiratory system has a dynamic mechanical structure that extends from the airways to the alveolar region. In addition, the epithelial, endothelial, stromal, and immune cells are highly organized in each region and interact with each other to function synergistically. These cells of varied lineage, particularly epithelial cells, have been difficult to use for long-term culture in vitro, thus limiting the development of useful experimental tools. This limitation has set a large distance between the bench and the bedside for analyzing the pathogenic mechanisms, the efficacy of candidate therapeutic agents, and the toxicity of compounds. Several researchers have proposed solutions to these problems by reporting on methods for generating human lung epithelial cells derived from pluripotent stem cells (PSCs). Moreover, the use of organoid culture, organ-on-a-chip, and material-based techniques have enabled the maintenance of functional PSC-derived lung epithelial cells as well as primary cells. The aforementioned technological advances have facilitated the in vitro

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Author

Atsushi Masui; Toyohiro Hirai; Shimpei Gotoh

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Environmental Science (Life Sciences)