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Thyroglobulin Measurement in Fine-needle Aspirates of Lymph Nodes in Patients with Differentiated Thyroid Cancer: a Simple Definition of the Threshold Value, with Emphasis on Potential Pitfalls of the Method by Claire Bournaud; Anne Charrié; Cécile Nozières; Karim Chikh; Véronique Lapras; Marie-Laure Denier; Christian Paulin; Myriam Decaussin-Petrucci; Jean-Louis Peix; Jean-Christophe Lifante; Catherine Cornu; Céline Giraud; Jacques Orgiazzi; Françoise Borson-Chazot is a Medicine article available to read on EtoBox.

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## Abstract **Background:** Thyroglobulin measurements in fine-needle aspirate (FNA-Tg) is an accurate method for the diagnosis of lymph node metastasis in differentiated thyroid carcinoma. The goal of this study is to determine the most appropriate diagnostic threshold value for FNA-Tg. **Methods:** Ultrasound-guided fine-needle aspiration-cytology (FNA-C) and FNA-Tg were performed on suspicious lymph nodes in 114 consecutive patients with thyroid cancer prior to thyroidectomy (n=13) or during follow-up (n=93), and in 16 control subjects. Functional sensitivity of the thyroglobulin assay was 0.7 ng/mL. Sensitivity and specificity of FNA-Tg and FNA-C were determined for different cut-off values within a range of 0.69–1.34 nanogram/punction (ng/p) using receiver operating characteristic curve analysis. **Results:** The FNA-Tg cut-off value of 0.93 ng/p offers the best diagnostic performances: 94.2% sensitivity, 97.8% specificity. FNA-C showed 100% specificity in diagnostic samples, but low sensitivity of 71% due primarily to inadequate samples. Combining FNA-C and FNA-Tg resulted in 98% sensitivity and 100% specificity. **Conclusions:** A unique threshold of 0.93 ng/p gives high sen

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Author

Claire Bournaud; Anne Charrié; Cécile Nozières; Karim Chikh; Véronique Lapras; Marie-Laure Denier; Christian Paulin; Myriam Decaussin-Petrucci; Jean-Louis Peix; Jean-Christophe Lifante; Catherine Cornu; Céline Giraud; Jacques Orgiazzi; Françoise Borson-Chazot

Publisher

Walter de Gruyter GmbH

Published

2010

Language

EN

Field

Medicine (Health Sciences)