Opening book details…
Can I read Evaluation of the Glucocorticoid Receptor as a Biomarker of Treatment Response in Vogt-Koyanagi-Harada Disease on EtoBox?
Evaluation of the Glucocorticoid Receptor as a Biomarker of Treatment Response in Vogt-Koyanagi-Harada Disease by Cristhian A. Urzua; Julia Guerrero; Hector Gatica; Victor Velasquez; Annelise Goecke is a Medicine article available to read on EtoBox.
What is Evaluation of the Glucocorticoid Receptor as a Biomarker of Treatment Response in Vogt-Koyanagi-Harada Disease about?
## Purpose: This study is aimed to investigate the role of glucocorticoid receptor (gr) isoforms in peripheral blood mononuclear cells (pbmc) as biomarkers of glucocorticoid (gc) resistance and to validate a set of clinical predictive factors in patients with vogt-koyanagi-harada (vkh) disease. ## Methods: This was a prospective cohort study that included a total of 21 patients with vkh. a complete ophthalmologic evaluation was carried out at baseline that recorded the presence of any clinical predictive factors (visual acuity ≤ 20/200, tinnitus, chronic disease, and fundus depigmentation). real-time quantitative pcr was performed to measure the mrna levels of gr alpha (grα) and beta (grβ) isoforms at baseline and at 2 weeks after prednisone therapy initiation. ## Results: There were no differences between grα and grβ levels in gc-sensitive and gc-resistant patients at baseline before treatment initiation. after 2 weeks of prednisone treatment, gc-sensitive patients had a median 5.5-fold increase in levels of grα, whereas gc-resistant patients had a median 0.7-fold decrease in levels of this isoform (p = 0.003). similarly, grβ increased in gc-sensitive patients, in comparison with
Who reads Evaluation of the Glucocorticoid Receptor as a Biomarker of Treatment Response in Vogt-Koyanagi-Harada Disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Cristhian A. Urzua; Julia Guerrero; Hector Gatica; Victor Velasquez; Annelise Goecke
- Publisher
- Association for Research in Vision and Ophthalmology (ARVO)
- Published
- 2017
- Language
- EN
- Field
- Medicine (Health Sciences)