Can I read C–H Functionalization Approach for the Synthesis of Chiral C2-Symmetric 1,5-Cyclooctadiene Ligands on EtoBox?
C–H Functionalization Approach for the Synthesis of Chiral C2-Symmetric 1,5-Cyclooctadiene Ligands by Bowen Zhang; Michael R. Hollerbach; Simon B. Blakey; Huw M. L. Davies is a Chemistry article available to read on EtoBox.
What is C–H Functionalization Approach for the Synthesis of Chiral C2-Symmetric 1,5-Cyclooctadiene Ligands about?
Chiral cyclooctadiene (COD) derivatives are readily prepared by rhodium-catalyzed allylic C−H functionalization of COD. Either mono-or difunctionalization of COD is possible generating the products in high yield, diastereoselectivity and enantioselectivity. The double C−H functionalization generates C 2 -symmetric COD derivatives with four new stereogenic centers in >99% ee, which can be readily converted to a series of chiral COD ligands. Preliminary evaluations revealed that the COD ligands can be used in rhodium-catalyzed asymmetric arylation of cyclohex-2-enone, leading to the conjugate addition products in up to 76% ee.
Who reads C–H Functionalization Approach for the Synthesis of Chiral C2-Symmetric 1,5-Cyclooctadiene Ligands?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Bowen Zhang; Michael R. Hollerbach; Simon B. Blakey; Huw M. L. Davies
- Published
- 2019
- Language
- EN
- Field
- Chemistry (Physical Sciences)