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Alkoxyacetyl (AAc) group as a useful linker for organic synthesis on poly(ethylene glycol) support by Masato Oikawa; Minoru Ikoma; Makoto Sasaki is a Chemistry article available to read on EtoBox.

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An alkoxyacetyl group (AAc) group was found to be an efficient linker for high-throughput synthesis of small molecules on a soluble polymer support. The linker allows high-yield loading of alcohols and phenols either by conventional carbodiimidemediated esterification or transesterification using Yb(OTf) 3 . Chemoselective cleavage to release small molecules is attained also by Yb(OTf) 3 or TMSCHN 2 . The preparation, protocols for loading and releasing of small molecules, and an application to the Ugi four-component coupling reaction are reported.

Who reads Alkoxyacetyl (AAc) group as a useful linker for organic synthesis on poly(ethylene glycol) support?

Author

Masato Oikawa; Minoru Ikoma; Makoto Sasaki

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)

Published

2004

Language

EN

Field

Chemistry (Physical Sciences)